Simultaneous increase in invasive cancer detection rate for women 40-49 from 1.6 (95% CI 1.2-1.9) to 2.7 (95% CI 2.2-3.1) with tomosynthesis (difference, 1.1 95% CI 0.6-1.6 P <. Largest recall rate reduction with tomosynthesis was for women 40-49, decreasing from 137 (95% CI 117-156) to 115 (95% CI 95-135) difference, -22 (95% CI -26 to -18 P <. Addition of tomosynthesis to digital mammography produced significant reductions in recall rates for all age groups and significant increases in cancer detection rates for women 40-69. Performance parameters were compared for women screened with digital mammography alone (n = 278,908) and digital mammography + tomosynthesis (n = 173,414). Screening metrics for women ages 40-49, 50-59, 60-69, and 70+, included rates per 1000 screens for recalls, biopsies, cancers, and invasive cancers detected. Screening performance metrics from 13 institutions were examined for 12 months prior to introduction of tomosynthesis (period 1) and compared to those after introduction of tomosynthesis (period 2, range 3-22 months). To determine the effect of tomosynthesis imaging as a function of age for breast cancer screening. 17 HonorHealth Breast Health and Research Center, Phoenix, AZ, USA.16 Invision Sally Jobe Breast Centers and Radiology Imaging Associates, Denver, CO, USA.15 Edith Sanford Breast Health Institute, Sioux Falls, SD, USA.14 Evergreen Health Breast Center and Radia Inc, Kirkland, WA, USA.13 Radiology Associates of Hollywood and Memorial Healthcare System, Hollywood, FL, USA.12 Washington Radiology Associates, Fairfax, VA, USA.11 University Hospitals Case Medical Center, Cleveland, OH, USA.10 Lynn Sage Comprehensive Breast Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.9 Caldwell Breast Center, Advocate Lutheran General Hospital, Park Ridge, IL, USA.8 Albert Einstein Healthcare Network, Philadelphia, PA, USA.7 Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. 6 Yale University School of Medicine, New Haven, CT, USA.5 Genomic Health, Redwood City, CA, USA.4 Solis Women's Health, Dallas, TX, USA.3 TOPS Comprehensive Breast Center, Houston, TX, USA. 1 Department of Radiology, Massachusetts General Hospital, Boston, MA, USA.
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